Biology Cell Cycle MCQs Chapter 7 Class 12

Biology Cell Cycle for Second Year Entry Tests and FSC Board Exams

Cell Cycle is a fundamental chapter in Second Year Biology that explains the process of cell growth, replication, and division. This topic is highly important for students preparing for MDCAT, NUMS, AKU, NUST, UET ECAT, and FSC Second Year board exams. Key concepts include phases of the cell cycle (G1, S, G2, M), mitosis, meiosis, checkpoints, and regulation of cell division, which are frequently tested in both MCQs and conceptual questions.

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Created on March 02, 2022 By Ali Durrani

Biology Ch 7 Class 12 Cell Cycle

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1 / 64

In gametogenesis, which resultant product is non-functional?

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) Spermatogonia

B) Oogonia

C) Polar body

D) Ovum

2 / 64

Diplotene is the sub-stage of:

NTS 2011
Biology
Cell Cycle
Elimination Tool:

A) Anaphase

B) Telephase I

C) Prophase I

D) Metaphase

3 / 64

During the formation of an ovum nondisjunction of the sex chromosomes occurred the ovum was then fertilized by a normal Y-bearing sperm cell which one of the following shows the sex chromosome complement of the resulting zygote?

NTS 2015 DUHS and JSMU
Biology
Cell Cycle
Elimination Tool:

A) XO

B) XXY

C) XXXY

D) XXYY

4 / 64

In plants mitotic apparatus consists of

Centriole

Centriole and asters

Centrioles, asters and spindles

Spindles only

5 / 64

Smooth endoplasmic reticulum is responsible for the metabolism of:

UHS 2019
Biology
Cell Cycle
Elimination Tool:

A) Nucleic acids

B) Proteins

C) Carbohydrates

D) Lipids

6 / 64

Crossing over takes place during _____ of meiosis.

UHS 2018
Biology
Cell Cycle
Elimination Tool:

A) Prophase I

B) Telophase I

D) Anaphase I

C) Metaphase I

7 / 64

During cell division, the spindle fibres get attached to condensing chromosome at a highly differentiated region. This region is called as:

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) Chromosome

B) Chromocentre

C) Centriole

D) Kinetochore

8 / 64

At what phase the DNA content of a cell is doubled?

PMC 2020
Biology
Cell Cycle
Elimination Tool:

A) Prophase

B) Interphase

C) Anaphase

D) Telophase

9 / 64

Which statement is incorrect?

In human, cell cycle is about 24 hrs

Mitosis takes 30 min

G2 5.5 hrs

Yeast cell only 90 min

10 / 64

From each pair of centrioles ________ sets of microtubules originate

11 / 64

Gametes are produced by:

PMC 2021 Tested
Biology
Cell Cycle
Elimination Tool:

A) Meiosis

B) Mitosis

C) None of these

D) Fission

12 / 64

The term bivalent means:

NUMS 2014
Biology
Cell Cycle
Elimination Tool:

A) Two chromatids

B) Two chromosomes

C) Four chromatids

D) Four chromosomes

13 / 64

Reduction division is:

NUMS 2015
Biology
Cell Cycle
Elimination Tool:

A) Amitosis

B) Mitosis

C) Meiosis I

D) Meiosis II

14 / 64

Period between two consecutive divisions is called

Interphase

Resting phase

Mitotic phase

Cell cycle

15 / 64

In which stage of meiotic division centromere divides?

NUMS 2017
Biology
Cell Cycle
Elimination Tool:

A) Anaphase I

B) Anaphase II

C) Metaphase II

D) Both A and B

16 / 64

Microtubules are composed of

Action protein

Actin and myosin proteins

Sphingomyelin and tubulin

Tubulin protein and traces of RNA

17 / 64

Interphase is a phase of the cell cycle defined only by the absence of _______.

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) Enzymes

B) DNA

C) Replication

D) Cell division

18 / 64

During which stage of meiosis do centromeres divide?

NTS 2016 DUHS & JSMU
Biology
Cell Cycle
Elimination Tool:

A) Prophase I

B) Metaphase I

C) Prophase II

D) Metaphase II

19 / 64

Chance of a cross over between two loci is directly proportional to their

UHS 2018
Biology
Cell Cycle
Elimination Tool:

A) Thickens

B) Width

C) Length

D) Distance

20 / 64

If a person has 44 autosomes + XXY, he will suffer from

UHS 2012
Biology
Cell Cycle
Elimination Tool:

A) Klinefelter’s syndrome

B) Down’s syndrome

C) Turner’s syndrome

D) Edward’s syndrome

21 / 64

The phase of mitosis in which sister chromatids move towards opposite poles:

UHS 2019
Biology
Cell Cycle
Elimination Tool:

A) Anaphase

B) Metaphase

C) Prophase

D) Telophase

22 / 64

During anaphase, each chromosome has:

PMC 2021 Tested
Biology
Cell Cycle
Elimination Tool:

A) One chromatid

B) Two chromatids

C) Several chromatids

D) No chromatids

23 / 64

Which of the following statements is true about metaphase?

PMC 2021 Tested
Biology
Cell Cycle
Elimination Tool:

A) Chromosomes are thickest during this phase

B) Chromosomes are shortest during this phase

C) Chromosomes are longest during this phase

D) Chromosomes are shortest and thickest during this phase

24 / 64

Reverse of prophase is

Interphase

Metaphase

Anaphase

Telophase

25 / 64

A special area of centromere with specific base arrangement and specific proteins where spindle fibers are attached is called

Chromatin

Aster

Kinetochore

Primary constriction

26 / 64

Which of the following is NOT true for meiosis?

NUMS 2019 Reconduct
Biology
Cell Cycle
Elimination Tool:

A) Number of chromosomes reduced to half

B) It takes place at the time of spore formation in plants

C) It takes place at the time of growth in animals

D) Two consecutive cell divisions are involved in it

27 / 64

Gametes in animals are produced by:

PMC 2021 Tested
Biology
Cell Cycle
Elimination Tool:

A) Meiosis

B) Fission

C) Mitosis

D) All three

28 / 64

Mitosis occurs in

Diploid cells only

Haploid cells only

Both diploid and haploid cells

Monoploid cells

29 / 64

In case of neurons, post mitotic cell escapes cell cycle and remain in _______ phase whthout proliferating further

G0 phase

G1 phase

G2 phase

S phase

30 / 64

Which of the following statements concerning nucleolus is correct?

NTS 2014
Biology
Cell Cycle
Elimination Tool:

A) It disappears at the time of cell division

B) There is only one nucleolus in every cell

C) It plays important role in the synthesis of ribonucleic acid and ribosomes in prokaryotic cells

D) It helps in destroying worn-out organelles

31 / 64

Which statement is not true about phragmoplast?

Formed from vesicle originating from Golgi apparatus

Present in plants only

Formed at the end of anaphase

Centre of dividing cell

32 / 64

Exchange of segments between homologous chromosomes is called:

UHS 2012
Biology
Cell Cycle
Elimination Tool:

A) Segregation

B) Independent assortment

C) Crossing over

D) Mutation

33 / 64

Each kinetochore gets ________ fibers in mitosis

34 / 64

Crossing over is an exchange of genes between _______ resulting in a mixture of parental characteristics in offspring.

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) Sister Chromatids

B) Non-homologous Chromosomes

C) Sex chromosomes

D) Homologous chromosomes

35 / 64

During interphase of the cell cycle, which of the following stage is for duplication of DNA:

NUMS 2019 Reconduct
Biology
Cell Cycle
Elimination Tool:

A) G0 phase

B) G1 phase

D) S phase

C) G2phase

36 / 64

The second stage of the Prophase of Meiosis, following Leptotene, during which homologous chromosomes begin to pair is called:

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) Anaphase

B) Zygotene

D) Pachytene

C) Diplotene

37 / 64

_______ is the most critical phase of mitosis.

NUMS 2015
Biology
Cell Cycle
Elimination Tool:

A) Prophase

B) Telophase

C) Anaphase

D) Metaphase

38 / 64

Microtubule subunits (for spindle fibers) are synthesized in _______ phase.

UHS 2019
Biology
Cell Cycle
Elimination Tool:

A) G1

B) M

C) G2

D) S

39 / 64

Process of uncontrolled cell division is due to which one of the following reasons?

NUMS 2018
Biology
Cell Cycle
Elimination Tool:

A) DNA replication

B) Mutations

C) Translation

D) Transcription

40 / 64

Spread of tumor cells and establishment of secondary areas of growth is

Benign tumors

Cancer

Metastasis

Epistasis

41 / 64

_______ is the stage of mitosis characterized by the physical separation of ________ chromatids.

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) Interphase. Offspring

B) Telophase, F1 chromatids

C) Metaphase, Homologous

D) Anaphase. Sister

42 / 64

Condensation of chromosomes reaches to the maximum during:

NUMS 2015
Biology
Cell Cycle
Elimination Tool:

A) Zygote

B) Pachytene

D) Diakinesis

C) Diplotene

43 / 64

Mitotic apparatus in animals is formed by

Aster and spindle

Polar and kinetochore microtubules

Spindle and RNA

Spindle only

44 / 64

Feature of cancer cells in common?

High nucleus to cytoplasmic ratio

Prominent nucleoli

Many mitosis

All of these

45 / 64

During meiosis, the homologous chromosomes come together and form pairs, this process is called:

PMC 2020
Biology
Cell Cycle
Elimination Tool:

A) Linkage

B) Synapsis

C) Pairing

D) Crossing over

46 / 64

In meiosis II, ______ differentiate into sperms.

NUMS 2019 Reconduct
Biology
Cell Cycle
Elimination Tool:

A) Spermatocytes

B) Spermatids

C) Sertoli cells

D) Polar bodies

47 / 64

Which is a feature of malignant tumor?

Localized

Little deleterious effect

Few mitosis

Metastasize

48 / 64

Gametes in animals are produced by which of the following?

PMC Practice 2
Biology
Cell Cycle
Elimination Tool:

A) Mitosis

B) Meiosis

C) Fission

D) All of these options are correct

49 / 64

Which of the following sub stages does not occur in prophase I?

NTS 2015 SMBBMC
Biology
Cell Cycle
Elimination Tool:

A) Leptotene

B) Zygotene

C) Synapsis

D) Diplotene

50 / 64

Synaptonemal complex helps in:

NUMS 2014
Biology
Cell Cycle
Elimination Tool:

Bac

A) Gamete formation

B) Recombination during cell division

C) Production of enzymes during cell division

D) Chromosomal movement towards pole

51 / 64

Most critical phase of mitosis is

Prophase

Anaphase

Metaphase

Telophase

52 / 64

Which of the following cells does not enter G0 phase?

NUMS 2020
Biology
Cell Cycle
Elimination Tool:

A) Nerve cells

B) Cells of cornea

C) Cells of lens

D) None of these

53 / 64

During the G2 phase:

UHS 2019
Biology
Cell Cycle
Elimination Tool:

A) Chromosome number is duplicated

B) The chromosomes are left with only one chromatid

C) Energy is stored for Chromosome movement and mitotic specific proteins(Tubulin) are produced

D) Specific enzymes are synthesized and DNA base units are accumulated

54 / 64

Which of the following is a type of cell division that plays an important role in evolution?

NTS 2019
Biology
Cell Cycle
Elimination Tool:

A) meiosis

B) mitosis

C) apoptosis

D) amitosis

55 / 64

Interphase of meiosis lacks

G0 phase

G1 phase

G2 phase

S phase

56 / 64

How does the second meiotic division differ from mitosis? In the second meiotic division:

NTS 2015 SMBBMC
Biology
Cell Cycle
Elimination Tool:

A) Chiasmata Formed between the chromatids of a bivalent

B) Each chromosome replicates to form two chromatids during metaphase

C) The separating chromatids of a pair differ genetically

D) None of the above

57 / 64

Meiosis occurs at the time of

Gamete formation in animals

Spore formattion in plants

Growth in animals

Both a and b

58 / 64

Synthesis of microtubules increases in:

UHS 2018
Biology
Cell Cycle
Elimination Tool:

A) M phase

B) S phase

C) G1 phase

D) G2 phase

59 / 64

Asexual offsprings can be produced by:

PMC 2021 Tested
Biology
Cell Cycle
Elimination Tool:

A) Mitosis

B) Meiosis

C) None of these

D) Both

60 / 64

Crossing over occur between ____________ of homologous chromosomes:

PMC Sample 1
Biology
Cell Cycle
Elimination Tool:

A) Sister pair of chromatid

B) Sister chromatids of homologous

C) Non-sister chromatin

D) All of them

61 / 64

Failure of separation of sister chromatids is called:

NUMS 2020
Biology
Cell Cycle
Elimination Tool:

A) Nonfusion

B) Nondisjunction

C) Fusion

D) Interference

62 / 64

At the beginning of nuclear division, the number of microtubule triplets in two pairs of centrioles that migrate to opposite poles are:

UHS 2015
Biology
Cell Cycle
Elimination Tool:

A) 9

B) 18

C) 108

D) 36

63 / 64

Meiosis occur in

Diploid cells only

Haploid cells only

Both diploid and haploid cells

Monoploid cells

64 / 64

DNA is synthesized and chromosome number is doubled in

G1 phase

S phase

G2 phase

G0 phase

Your score is

The average score is 58%

Importance of Cell Cycle in Competitive Biology

A clear understanding of the Cell Cycle helps students explain cell growth, DNA replication, chromosomal segregation, and cell division errors. Topics such as mitotic and meiotic phases, cyclins, cyclin-dependent kinases, and consequences of abnormal cell division are commonly asked in entry tests. Practicing chapter-wise MCQs, diagrams, and topic-wise exercises strengthens conceptual clarity, improves accuracy, and enhances exam performance.

Effective Preparation and Practice Resources for Second Year Students

Effective preparation for the Cell Cycle includes systematic revision, MCQ practice, and mock testing. Solving past papers and exam-focused questions helps students identify key areas and frequently tested concepts. PLS Academy provides structured learning resources that enable students to master the Cell Cycle and perform confidently in medical entry tests and FSC Second Year board examinations.

JazakAllah.